Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1β and IL-18 in the Septic Response
Establishment of LPS-stimulated THP-1 sepsis model. (a, b) Immunoblots showing caspase-1 and GSDMD levels in the THP-1 treated with LPS for 0, 4, 8, 12, and 24 h. (c). LDH content in the supernatant at the different time points. (d, e) IL-1β and IL-18 secretion in the supernatant following LPS stimulation. ,,, and .
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