Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1β and IL-18 in the Septic Response
RAPA abrogates the effect of 4 h LPS stimulation in HUVECs. (a, b) Immunoblot showing the levels of caspase-1, GSDMD, LC3II, and LC3I. (c) Electron microscopy images showing autophagosomes in the (A) LPS- and (B) LPS+RAPA-treated HUVECs. (d) Relative concentration of LDH in the supernatant. (e) IL-18 content released into the supernatant. and .
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