Review Article

Onlay Repair Technique for the Management of Ureteral Strictures: A Comprehensive Review

Table 3

Preclinical studies regarding tissue engineering-based ureteroplasty.

Authors and yearAnimal model, Type of scaffoldLength of repair (cm)Follow-up (weeks)Functional outcomes of recipient siteRegeneration outcomes of recipient site

Liatsikos et al. (2001) [58]Pig (F), 6SIS (onlay)77Good patency and anastomosesU, S, N
Smith et al. (2002) [59]Pig (F), 9SIS (onlay)29Good patencyU (with focal intestinal metaplasia), S, N
Greca et al. (2004) [68]Pig, 10SIS (onlay)25.7Good patency in 7, fistula in 1, restenosis in 2U and N (in 100% cases), S (in 87.5%)
Duchene et al. (2004) [69]Pig, 12SIS (onlay in 5, tube in 7)26 or 9Patent in patch group, complete obstruction in tube groupPatch group: U, S, Fi, and I (mild); tube group: U, S (partial), F (dense)
El-Hakim et al. (2005) [70]Pig (F), 8SIS (tube)+UCs/SMCs56Contraction and stenosisU, S, Fi (dense)
de Jonge et al. (2018) [71]Pig (F), 20Collagen-Vicryl (tube)512.8ContractionU (in 32% cases), S (in 50%), N
de Jonge et al. (2018) [72]Goat (F), 12Collagen-Vicryl (tube)+subcutis1.5-3.512.8Patent in 8, urine leakage in 2, stenosis in 2U, N, S (limited to the anastomosis sites), I (mild)

F: female; SIS: small intestine submucosa; UCs: urothelial cells; SMCs” smooth muscle cells; U: urothelial regeneration; S: smooth muscle ingrowth; N: neovascularization; Fi: fibrosis; I: inflammation.