Valuable Role of Neutrophil CD64 and Highly Sensitive CRP Biomarkers for Diagnostic, Monitoring, and Prognostic Evaluations of Sepsis Patients in Neonatal ICUs
Table 1
Comparison between the sepsis and control groups as regards clinical and laboratory data.
Parameter
Sepsis group ()
Control group ()
value
Preterm
54 (60.7%)
14 (47%)
0.180
LBW and VLBW
48 (53.2%)
10 (34.4%)
0.14
Male gender
47 (51.1%)
14 (47%)
0.674
Early onset sepsis
47 (51.64 %)
NA
NA
Respiratory distress
65 (71.4%)
2 (6.7%)
<0.001
Respiratory support
52 (57.1%)
0 (0%)
<0.001
Surgical interventions
20 (21.97%)
0 (0%)
<0.001
Nosocomial infection
38 (41.75%)
NA
NA
Deaths
30 (33%)
0 (0%)
0.01
DOH
24 (3-127)
5.5 (1–35)
<0.001
Hb (g/dL)
13.2 (8-21.4)
13 (6.4–23)
0.755
TLC (×109/L)
15.3 (1-52)
14.4 (6.6–29)
0.281
ANC (×109/L)
7.7 (0.6-40)
5 (1.6–14)
0.198
Platelet (×109/L)
248 (15-620)
294 (70–587)
0.02
ratio
0 (0- 0.9)
0 (0–0)
0.007
hs-CRP (mg/L)
10 (0-110.5)
0 (0–10)
<0.001
nCD64%
86 (46.7- 99.5)
26.2 (40.6–52.7)
<0.001
nCD64 MFI
1.84 (1.04- 4.62)
1.42 (1.05–3.56)
0.002
Values are presented as the median and IQR or number (%). (probability value). DOH: duration of hospitalization; LOW: low birth weight; VLBW: very low birth weight; Hb: hemoglobin; TLC: total leukocyte count; ANC: absolute neutrophil count; ratio: immature/total neutrophil ratio; hs-CRP: highly sensitive CRP; nCD64%: neutrophil CD64%; nCD64MFI: nCD64 mean fluorescence intensity; NA: not available.
