Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis
Table 1
Baseline characteristics of CH MetS cohort and those who developed MetS, overweight and obesity, hyperglycemia, hypertension, and dyslipidemia during follow-up.
Characteristic
Entire cohort (n = 1381)
MetS (n = 61)
Overweight and obesity (n = 125)
Hyperglycemia (n = 54)
Hypertension (n = 144)
Dyslipidemia (n = 169)
Age, year
39.48 (12.05)
53.98 (12.03)
42.90 (11.27)
51.46 (12.90)
45.08 (11.90)
45.90 (12.50)
Smoker, n (%)
5 (0.36)
0 (0.00)
2 (1.60)
0 (0.00)
1 (0.69)
0 (0)
Drinker, n (%)
89 (6.46)
4 (6.67)
11 (8.87)
5 (9.43)
10 (6.94)
9 (5.36)
BMI (kg/m2)
22.28 (3.07)
26.59 (3.14)
23.61 (1.36)
25.43 (3.26)
24.21 (3.60)
23.70 (3.04)
FBS (mmol/L)
5.02 (0.53)
5.48 (0.81)
5.12 (0.63)
5.53 (0.35)
5.21 (0.66)
5.18 (0.60)
SBP (mmHg)
119.38 (15.04)
134.18 (15.90)
121.34 (15.13)
130.80 (16.08)
126.56 (9.08)
125.41 (15.64)
DBP (mmHg)
72.79 (9.77)
79.67 (9.92)
73.34 (9.18)
77.39 (12.35)
78.22 (7.32)
75.70 (9.90)
TG (mmol/L)
0.95 (0.53)
1.53 (0.85)
1.07 (0.46)
1.40 (0.93)
1.17 (0.69)
1.12 (0.33)
LDL-c (mmol/L)
2.65 (0.68)
3.13 (0.66)
2.71 (0.61)
3.01 (0.64)
2.89 (0.69)
2.97 (0.63)
HDL-c (mmol/L)
1.59 (0.30)
1.43 (0.29)
1.55 (0.26)
1.49 (0.35)
1.57 (0.31)
1.52 (0.24)
Hypoglycemia drugs, n (%)
14 (1.02)
4 (7.02)
5 (4.03)
0 (0)
6 (4.20)
2 (1.21)
Antihypertensive drugs, n (%)
46 (3.41)
11 (20.00)
4 (3.36)
5 (10.00)
0 (0)
12 (7.55)
Lipid lowering drugs, n (%)
15 (1.12)
2 (3.77)
2 (1.64)
1 (2.00)
2 (1.46)
0 (0)
UA (μmol/L)
257.33 (52.80)
286.26 (62.94)
258.56 (50.37)
273.63 (57.91)
269.64 (54.22)
263.98 (52.24)
Data are mean (standard deviation) for continuous variables and number (%) of nonmissing observations for each binary variable. BMI = body mass index; FBS = fasting blood glucose; SBP = systolic blood pressure; DBP = diastolic blood pressure; TG = triglycerides; HDL-C = high-density lipoprotein cholesterol; UA = uric acid; MetS = metabolic syndrome. , univariate cox proportional hazards regression analyses with MetS or four MetS components. , univariate cox proportional hazards regression analyses with MetS or four MetS components.
