Research Article

Exosomal circLPAR1 Promoted Osteogenic Differentiation of Homotypic Dental Pulp Stem Cells by Competitively Binding to hsa-miR-31

Figure 7

Overview hypothesis of the present study: exosomes derived from osteogenic-induced DPSCs rich in circLPAR1; then, the exosomes were phagocytosed by the recipient homotypic DPSCs and lift up the expression level of circLPAR1 in the recipient cells. Afterwards, circLPAR1 could competently bind to miR-31, thereby eliminating the inhibitory effect of miR-31 on osteogenic differentiation, as a consequence of promoting osteogenic differentiation of the recipient homotypic DPSCs.