BioMed Research International / 2020 / Article / Tab 5

Research Article

Integrated Analysis of a Gene Correlation Network Identifies Critical Regulation of Fibrosis by lncRNAs and TFs in Idiopathic Pulmonary Fibrosis

Table 5

Functional roles of the strongest correlations of lncRNAs and TFs in IPF.

No.Gene symbolFull nameFunction

1MALAT1Metastasis-associated lung adenocarcinoma transcript 1Form molecular scaffolds for ribonucleoprotein complexes, acting as a transcriptional regulator for numerous genes, and involved in cell cycle regulation
2RNU1-1RNA, U1 small nuclear 1Its related pathways are spliceosomal splicing cycle
3FENDRRFOXF1 adjacent noncoding developmental regulatory RNABind to polycomb repressive complex 2 and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes
4TUG1Taurine upregulated 1Interacts with the polycomb repressor complex and functions in the epigenetic regulation of transcription, acting as a sponge for microRNAs
5E2F1E2F transcription factor 1Bind preferentially to retinoblastoma protein pRB in a cell cycle-dependent manner and mediate both cell proliferation and p53-dependent/independent apoptosis
6TP53Tumor protein P53Regulate expression of target genes, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism
7SP1Sp1 transcription factorBe involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling
8YBX1Y-box binding protein 1Be implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation, and mRNA packaging
9BRCA1Breast cancer type 1 susceptibility proteinPlay a role in transcription, DNA repair of double-stranded breaks, and recombination which forms a large multisubunit protein complex known as the BRCA1-associated genome surveillance complex and interacts with histone deacetylase complexes
10E2F4E2F transcription factor 4Act as proliferation-associated suppression genes and bind to all three of the tumor suppressor proteins pRB, p107, and p130
11CREB1CAMP responsive element binding protein 1Its related pathways are development of HGF signaling pathway and circadian entrainment
12CIITAClass II major histocompatibility complex transactivatorOnce it does not bind DNA but rather uses an intrinsic acetyltransferase activity to act in a coactivator-like fashion

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