Patterns and Direct/Indirect Signaling Pathways in Cardiovascular System in the Condition of Transient Increase of NO

Figure 3

(a) Time-dependent changes of HPs of anesthetized rat after i.v. bolus administration of 32 nmol kg⁻¹ GSNO (marked by black dash lines). The minimum value of systolic BP is marked by pink dash lines. The red line starts 3 s before GSNO administration. The red part of the curve corresponds to the decrease of systolic BP and the blue one to the increase of systolic BP. (b) Relationships of HPs to systolic BP after administrations of 32 nmol kg⁻¹ GSNO. The red line represents the decrease of systolic BP from the control BP before GSNO administration to the lowest BP, and the blue line represents the increase of systolic BP from the lowest systolic BP to the control systolic BP ((A) or (AA) of (a)). The hysteresis was arbitrary defined as HP-systolic of systolic BP. (c) Nonhysteresis/hysteresis patterns of the relationships of HPs to systolic BP after administrations of 32 nmol kg⁻¹ GSNO. Data were taken from (b) and S2. The total number of rats in which nonhysteresis (blue) or hysteresis (red) patterns were observed is . The hysteresis was arbitrarily defined as HP-systolic of systolic BP.

(a)

(b)

(c)