Review Article

Disease-Associated Circular RNAs: From Biology to Computational Identification

Table 3

A list of web databases for circRNA studies.

NameYearFunctionsDatabase linksLast updatedRefs.

Circ2Traits2013A database for circRNAs with potential disease association, observed from GWAS-associated SNPs and potential interactions with miRNAshttp://gyanxet-beta.com/circdb/
https://github.com/shaoli86/circ2Traits
11-18-2019[131]
circBase2014A web server-based database for circRNAshttp://circbase.org/12-15-2015[132]
SomaniR v2.02016A database of cancer somatic mutation in miRNA and target sites to interact with miRNAs or circRNAs and mRNAshttp://compbio.uthsc.edu/SomamiR/NA[198]
CircNet2016A database providing resources of novel circRNAs, integrated miRNA-target network, expression, annotations, and sequences of circRNA isoformshttp://circnet.mbc.nctu.edu.tw/ (NA)
https://omictools.com/circnet-tool
NA[146]
circRNADb2016A circRNA database containing >32k human exonic circRNAshttp://reprod.njmu.edu.cn/cgi-bin/circrnadb/circRNADb.php03-03-2016[147]
TSCD2017An integrated database (tissue-specific circRNA database) to deposit features of tissue-specific circRNAshttp://gb.whu.edu.cn/TSCD/NA[148]
CIRCpedia v22018An updated database for comprehensive circRNA annotation from >180 RNA-seq datasetshttps://www.picb.ac.cn/rnomics/circpedia/
https://www.picb.ac.cn/rnomics/circpedia_v1/
07-07-2018[149]
CircR2Disease2018A curated database for circRNAs which is experimentally supportedhttp://bioinfo.snnu.edu.cn/CircR2Disease/ (NA)03-31-2018[150]
exoRBase2018A database of circRNAs, lncRNAs, and mRNAs from RNA-seq data of human blood exosomeshttp://www.exorbase.org/07-2017[151]
TRCirc2018A database for providing information on transcriptional regulation of circRNAshttp://www.licpathway.net/TRCirc/view/indexNA[152]
CircRNAdisease2018A curated database of circRNAs and disease associationhttp://cgga.org.cn:9091/circRNADisease/04-27-2018[153]
Circbank2019A database of human circRNAs from different sourceshttp://www.circbank.cn/NA[154]
CircFunBase2019A database with functional circRNA resources including predicted functions that have been experimentally validatedhttp://bis.zju.edu.cn/CircFunBase/10-08-2019[155]
LncACTdb 2.02019A database of endogenous RNAs including circRNAshttp://www.bio-bigdata.net/LncACTdb/NA[156]
CropCircDB2019A circRNA database for crops in response to abiotic stresshttp://genome.sdau.edu.cn/crop/
http://deepbiology.cn/crop/
05-10-2018[157]
AtCircDB2019A tissue-specific database for Arabidopsis circRNAshttp://genome.sdau.edu.cn/circRNA (NA)NA[158]
MiOncoCirc2019A most comprehensive database of cancer-based circRNAs, providing a reference of circRNAs from cancer cell lines and tumor tissueshttps://mioncocirc.github.io/NA[23, 199]
Circad2020A curated database of circRNAs associated with diseaseshttp://clingen.igib.res.in/circad/NA[144]
ncrpheno2020A database that integrates and annotates ncRNA-disease association datahttp://lilab2.sysu.edu.cn/ncrpheno (NA)NA[159]
NPInter v42020An integrated database of nvRNA interaction, including circRNA interactionhttp://bigdata.ibp.ac.cn/npinter409-2019[160]
CircAtlas 2.02020An integrated database that contains >1 million highly reliable circRNAs in vertebrateshttp://circatlas.biols.ac.cn/03-30-2020[161]
VirusCircBase2020A database of virus circRNAs, providing fundamental atlas for further studyhttp://www.computationalbiology.cn/ViruscircBase/home.html01-30-2020[162]

NA: not applicable. Last access date: 05-25-2020.