Prediction Model of HBsAg Seroclearance in Patients with Chronic HBV Infection

Table 1

Demographics and clinicopathologic characteristics of chronic hepatitis B patients enrolled in the study.

	Training set ()		Validation set ()
Variable	No. of patients	%	No. of patients	%
Gender					0.080
Male	668	72.77	370	77.08
Age (years)	34.91 (28.96, 42.75)		35.99 (29.34, 42.68)		0.243
<40	610	66.45	307	63.96
≥40; <60	274	29.85	156	32.50
≥60	34	3.70	17	3.54
BMI (kg/m^2)	21.80 (19.82, 24.35)		22.04 (19.65, 24.69)		0.448
<18.5	120	13.07	63	13.13
≥18.5; <25	606	66.01	305	63.54
≥25; <30	180	19.61	108	22.50
≥30	12	1.31	4	0.83
History of alcohol intake	98	10.68	60	12.50	0.306
Family history of HBV	556	60.57	294	61.25	0.804
Family history of HCC	96	10.46	54	11.25	0.649
HCC					0.186
HCC on inclusion	11	1.20	8	1.67
New-onset HCC	3	0.33	5	1.04
AST (U/l)	36 (26, 59)		35 (26, 66)		0.726
≥15; <40	519	56.54	274	57.08
≥40	390	42.48	204	42.50
ALT (U/l)	38 (24, 76)		38 (25, 72)		0.917
≥3; <35	420	45.75	222	46.25	0.859
≥35	498	54.25	258	53.75	0.859
Albumin (g/l)	45.50 (43.39, 47.60)		45.30 (42.90, 47.48)		0.239
<36	35	3.81	13	2.71	0.282
Total bilirubin (μmol/l)	13.84 (10.89, 18.70)		14.24 (10.33, 18.70)		0.933
>23.6	110	11.98	65	13.54	0.403
HBV DNA log10 (IU/ml)	4.750 (0, 6.945)		4.197 (0, 6.679)		0.118
<2	233	25.38	127	26.46
≥2; <4	163	17.76	105	21.88
≥4; <7	300	32.68	148	30.83
>7	222	24.18	100	20.83
qHBsAg log10 (IU/ml)	3.673 (3.200, 3.862)		3.738 (3.218, 3.888)		0.235
≤1	18	1.96	11	2.29
>1; ≤2	30	3.27	16	3.33
>2; ≤3	123	13.40	57	11.88
>3	747	81.37	396	82.50
HBeAg status					0.504
Positive	482	52.51	243	50.63
Negative	436	47.49	237	49.38
HBsAg loss	35	3.81	22	4.58	0.489
Antiviral treatment	666	72.55	346	72.08	0.853
Follow-up time (months)	75 (52, 90)		75 (51, 89)		0.905

Abbreviations: CHB: chronic hepatitis B; BMI: body mass index; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; ALT: alanine aminotransferase; AST: aspartate aminotransferase; HBV DNA: hepatitis B viral deoxyribonucleic acid load at baseline; qHBsAg: quantitative hepatitis B virus surface antigen; HBeAg: hepatitis B virus e-antigen.