Perspectives of the Application of Liquid Biopsy in Colorectal Cancer

Table 3

Exosomal miRNAs as emerging liquid biopsy markers in CRC.

Exosomal miRNAs	Methods	Expression change	Potential clinical utility	Reference
miR-21	Amplification-free assay for electrochemical detection and qRT-PCR	Upregulation	Screening and prognostic	[130]
miR-25-3p	Microarray analysis and RT-PCR	Upregulation	Diagnostic and therapeutic	[131]
miR-200b	Northern blot and qRT-PCR	Upregulation	Diagnostic and therapeutic	[132]
miR-150-5p	qRT-PCR	Downregulation	Prognostic	[134]
miR-6803-5p	qRT-PCR	Upregulation	Diagnostic and prognostic	[135]
miR-19a, miR-92a	Microarray analysis and qRT-PCR	Upregulation	Prognostic	[136]
miR-21-5p, miR-1246, miR-1229-5p, miR-96-5p	qRT-PCR	Upregulation	Monitoring and treatment of chemoresistance	[137]

Abbreviations: qRT-PCR: quantitative real-time PCR; RT-PCR: reverse transcription PCR.