Sequence Analysis and Structure Prediction of SARS-CoV-2 Accessory Proteins 9b and ORF14: Evolutionary Analysis Indicates Close Relatedness to Bat Coronavirus

Table 3

Predicted functions of SARS-CoV-2 9b and ORF14 proteins with respective ProFunc score (shown within parenthesis).

Protein name	Summary of predicted function
	Protein name terms	Gene ontology (GO) terms
		Cellular component	Biological process	Biochemical function
9b protein	SARS coronavirus ORF9b (0.90) aquifex aeolicus trbp111 structure-specific (0.50) aeolicus trbp111 structure-specific trna (0.50) trbp111 structure-specific trna binding (0.50) ustilago maydis lipase um03410 (0.50) maydis lipase um03410 short (0.50) lipase um03410 short form (0.50) um03410 short form without (0.50)	Extracellular region (1.33) cytoplasm (0.85)	Cellular process (1.66) cellular metabolic process (1.66)	tRNA binding (0.50) RNA binding (0.50) aminoacyl\-tRNA ligase activity (0.50) binding (0.50)
ORF14 protein	Human (1.72) domain (1.56) atcc (1.00) nmr (1.00) aminoimidazole riboside kinase (0.70) phycocyanin (0.57) ccm3 (0.50) c-terminal regulatory domain stk25 (0.50)	Cytoplasm (1.86) cell (1.86) cell part (1.86) intracellular (1.86)	Metabolic process (3.06) cellular process (2.27) cellular metabolic process (2.27) primary metabolic process (1.53)	Catalytic activity (2.91) binding (2.48) metal ion binding (1.61) ion binding (1.61)