PredDBP-Stack: Prediction of DNA-Binding Proteins from HMM Profiles using a Stacked Ensemble Method

Table 3

Performance comparison on the benchmark dataset PDB1075.

Method	OA (%)	SN (%)	SP (%)	MCC	AUC
DNA-Prot	72.55	82.67	59.76	0.44	0.7890
iDNA-Prot	75.40	83.81	64.73	0.50	0.7610
iDNA-Prot|dis	77.30	79.40	75.27	0.54	0.8260
DNABinder	73.95	68.57	79.09	0.48	0.8140
Kmerl+ACC	75.23	76.76	73.76	0.50	0.8280
iDNAPro-PseAAC	76.76	75.62	77.45	0.53	0.8392
Local-DPP	79.20	84.00	74.50	0.59	—
HMMBinder	86.33	87.07	85.55	0.72	0.9026
StackDPPred	89.96	91.12	88.80	0.80	0.9449
Our method	92.42	92.47	92.36	0.85	0.9677