PredDBP-Stack: Prediction of DNA-Binding Proteins from HMM Profiles using a Stacked Ensemble Method

Table 4

Performance comparison on the independent dataset PDB186.

Method	OA (%)	SN (%)	SP (%)	MCC	AUC
DNA-Prot	61.80	69.90	53.80	0.240	0.7960
iDNA-Prot	67.20	67.70	66.70	0.334	0.8330
iDNA-Prot|dis	72.00	79.50	64.50	0.445	0.7860
DNABinder	60.80	57.00	64.50	0.216	0.6070
Kmerl+ACC	70.96	82.79	59.13	0.431	0.7520
iDNAPro-PseAAC	69.89	77.41	62.37	0.402	0.7754
Local-DPP	79.00	92.50	65.60	0.625	—
HMMBinder	69.02	61.53	76.34	0.394	0.6324
StackDPPred	86.55	92.47	80.64	0.736	0.8878
Our method	86.56	87.10	86.02	0.731	0.8932