Leptin Overexpression as a Poor Prognostic Factor for Colorectal Cancer

Table 1

Relationships between leptin expression and the clinical profiles of CRC.

Factor	(%)	Leptin expression		value
		Strong	Low
Age
≥65	91	45	46
<65	316	165	151	0.73
Gender
Male	236	127	109
Female	171	93	78	0.99
Tumor location
Colon	189	94	95
Rectum	218	116	102	0.55
Histologic grading
Low grade, moderate grade	365	192	173
High grade	42	18	24	0.30
Preoperative CEA level (ng/mL)
≤5	181	97	84
>5	226	113	113	0.53
Lymph node involvement
Yes	197	142	55	<0.01
No	210	68	142
T stage
T3	128	74	54
T4	279	136	143	0.11
M stage
M0	206	87	119
M1	201	123	78	<0.01
Adjuvant therapy
Yes	374	192	182
No	33	18	15	0.86
MSI
MSS/MSI-L	372	194	178
MSI-H	35	16	19	0.58

CEA: carcinoembryonic antigen; MSI: microsatellite instability; MSS: microsatellite stable; MSI-L: microsatellite instability-low; MSI-H: microsatellite instability-high; T stage: tumor stage; M stage: distant metastasis.