Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study

Table 4

Analysis of nsSNP effect on hydrogen bonds and hydrophobic interactions.

dbSNP ID	SNP	Hydrogen bonds		Hydrophobic bonds
		Wild type	Variant	Wild type	Variant
rs515726181	R41P	Ile 44 and Glu 119 (2)	—	Gln 48	—
rs200273673	R41W	Ile 44 and Glu 119 (2)	—	Gln 48	—
rs267607025	R110P	Glu 114, Asp 178, Ile 176, and Asn 106	Glu 114	Glu 109	Ile 176 and Phe 111
rs515726187	F123S	Glu 119 and Gln 127	Glu 119 and Gln 127	Phe 234	Phe 234
rs1211197364	Y124C	Ile 128 and Ala 120	Ile 128 and Ala 120	Ser 112, Leu 107, Phe 111, and Phe 234	Ser 112
rs1185904532	E131A	Gln 127 (2) and Ser 135	Gln 127 and Ser 135	Gln 127	—
rs515726188	E131K	Gln 127 (2) and Ser 135	Gln 127 and Ser 135	Gln 127	Asp 100, Val 103, and His 231
rs1313813193	S139R	Ser 135, Asp 143, and Phe 45	Ser 135 and Asp 143	Phe 45	Phe 45 and Ile 44
rs1169870960	I142T	Tyr 138 and Ile 146	Tyr 138 and Ile 146	Phe 156, Ala 97, and Leu 93	Phe 156
rs515726190	R186G	Glu 114 (2), Phe 190, Thr 182, and Ser 181	Phe 190 and Thr 182	Phe 111	—
rs515726191	E194G	Phe 190	Phe 190	—	Phe 198
rs121918308	E194K	Phe 190	Phe 190 (2)	—	His 231
rs515726192	G195R	Ala 191	Ala 191 and Cys 232	—	Val 289
rs863224192	G200E	Ala 204	Ala 204	—	Ile 286
rs1283028277	F206V	Phe 202 and Lys 210	Phe 202 and Lys 210	Phe 311, Met 312, and Glu 222	Phe 311
rs575109470	G216R	Asp 74 and Ser 220 (2)	Asp74 and Ser 220 (2)	Leu 71	—
rs1422185855	D227V	Leu 223, Arg 226 (2), Trp 64, and His 231	Leu 223 and His 231	—	His 231
rs772868983	H231Q	Asp 227 and Ala 235	Asp 227 and Ala 235	Gln 127	—
rs1215473912	A235T	His 231 and Phe 239	His 231 and Phe 239	Ala 191 and Val 187	Ala 191

(2): two interactions with the same residue.