Identification of Vinculin as a Potential Diagnostic Biomarker for Acute Aortic Dissection Using Label-Free Proteomics

Table 2

Differentially expressed proteins (FC>1.5 or <0.667) in AAD identified by label-free proteomics.

Accession	Gene name	Protein name	Biological process	AAD/AMI ratio	AAD/HC ratio
Increased in AAD
P18206	VCL	Vinculin	Adherens junction assembly	4.85	8.33
P0DJI8	SAA1	Serum amyloid A-1 protein	Activation of MAPK activity	2.36	5.58
Q16627	CCL14	C-C motif chemokine 14	Cellular calcium ion homeostasis	4.61	4.89
P01034	CST3	Cystatin-C	Extracellular fibril organization	2.15	4.47
Q16270	IGFBP7	Insulin-like growth factor-binding protein 7	Cell adhesion	2.12	4.44
Q99972	MYOC	Myocilin	Positive regulation of focal adhesion assembly	3.86	4.14
P18065	IGFBP2	Insulin-like growth factor-binding protein 2	Aging	4.62	3.98
P98160	HSPG2	LG3 peptide	Angiogenesis	3.85	3.76
Q15828	CST6	Cystatin-M	Anatomical structure morphogenesis	2.22	2.96
P20774	OGN	Mimecan	Negative regulation of smooth muscle cell proliferation	3.45	2.79
P07737	PFN1	Profilin-1	Actin cytoskeleton organization	2.95	2.48
P80723	BASP1	Brain acid soluble protein 1	Diaphragm development	1.57	2.45
P02750	LRG1	Leucine-rich alpha-2-glycoprotein	Brown fat cell differentiation	1.74	2.36
P61769	B2M	Beta-2-microglobulin	Antibacterial humoral response	2.24	2.06
P14543	NID1	Nidogen-1	Basement membrane organization	1.53	1.73
Decreased in AAD
Q13103	SPP2	Secreted phosphoprotein 24	Bone remodeling	0.51	0.24
P00915	CA1	Carbonic anhydrase 1	Bicarbonate transport	0.27	0.29
P05543	SERPINA7	Thyroxine-binding globulin	Thyroid hormone transport	0.24	0.33
P01871	IGHM	Ig mu chain C region	Adaptive immune response	0.58	0.42
A2RTY3	HEATR9	Protein HEATR9	Hematopoietic progenitor cell differentiation	0.54	0.45
P02787	TF	Serotransferrin	Cellular iron ion homeostasis	0.42	0.47
P01023	A2M	Alpha-2-macroglobulin	Blood coagulation, intrinsic pathway	0.46	0.56

AAD: acute aortic dissection; AMI: acute myocardial infarction.