Research Article
Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis
Table 1
Characteristics of case-control studies.
| | Author [Ref] | Country | Ethnicity | Age | Sepsis source | Sepsis type | SNP method | HWE | Primer | BM | Sepsis definition |
| | Stuber et al. [11] | Germany | Caucasian | >18 | ICU | SS | PCR | Yes | Yes | No | Yes | | Stuber et al. [12] | Germany | Caucasian | NA | ICU | SS | PCR | Yes | Yes | No | Yes | | Fang et al. [13] | Germany | Caucasian | >18 | ICU | SS | PCR | No | Yes | No | Yes | | Majetschak et al. [14] | Germany | Caucasian | ≥18 | Trauma | SS | PCR | Yes | Yes | No | Yes | | Schroder et al. [15] | Germany | Caucasian | >18 | ICU | S | PCR | Yes | Yes | No | Yes | | Schroeder et al. [16] | Germany | Caucasian | >18 | SICU | SS | PCR | Yes | Yes | No | Yes | | Waterer et al. [17] | American | Mixed | ≥18 | CAP | SS | PCR | Yes | Yes | Yes | Yes | | Rauchschwalbe et al. [18] | Germany | Caucasian | >18 | Surgery | S, SS | MS-PCR | Yes | Yes | No | Yes | | Majetschak et al. [19] | Netherland | Caucasian | ≥18 | Trauma | SS | PCR-RFLP | Yes | Yes | No | Yes | | Schaaf et al. [20] | Germany | Caucasian | ≥18 | CAP | S, SS, SSH | PCR | Yes | Yes | No | Yes | | Calvano et al. [21] | American | Mixed | ≥18 | SICU | SH, S | PCR | Yes | Yes | Yes | Yes | | Zhang 1 et al. [22] | China | Asian | ≥18 | ASP | SH | PCR | No | Yes | No | Yes | | Zhang 2 et al. [23] | China | Asian | ≥18 | ASBP | SH | PCR | No | Yes | No | Yes | | Balding et al. [24] | Ireland | Caucasian | Child | Sepsis | S | PCR | No | Yes | No | No | | Riese et al. [25] | Germany | Caucasian | >18 | Surgery | S | PCR | No | Yes | No | Yes | | Kahlke et al. [26] | Germany | Caucasian | ≥18 | Surgery | S | PCR-RFLP | Yes | Yes | No | Yes | | Gordon et al. [27] | UK | Caucasian | ≥18 | ICU | SS, SSH | PCR-RFLP | Yes | Yes | Yes | Yes | | Nakada et al. [28] | Japan | Asian | ≥18 | ICU | S | PCR-RFLP | Yes | Yes | No | Yes | | Watanabe et al. [37] | Japan | Asian | >18 | ICU | S, SSH | PCR | NA | Yes | No | Yes | | Schueller et al. [30] | Germany | Caucasian | Infant | Sepsis | S | PCR | Yes | Yes | Yes | Yes | | Garnacho et al. [31] | Spain | Caucasian | >18 | ICU | S, SS, SSH | PCR | Yes | Yes | No | Yes | | García-Segarra et al. [32] | Spain | Caucasian | >18 | ICU | S, SS, SSH | PCR | Yes | No | No | Yes | | Menges et al. [33] | Germany | Caucasian | ≥18 | Trauma | S | PCR | Yes | Yes | Yes | Yes | | Read et al. [34] | UK | Mixed | Mix | Sepsis | S | PCR | Yes | Yes | No | No | | Carregaro et al. [35] | Brasil | Mixed | ≥18 | ICU | S, SS, SSH | Taqman | Yes | Yes | No | Yes | | Gu et al. [36] | China | Asian | ≥18 | Trauma | S | PCR | Yes | No | No | Yes | | Watanabe et al. [37] | American | Mixed | ≥18 | ICU | S, SS | PCR | No | No | Yes | Yes | | Sole-Violan et al. [38] | Spain | Caucasian | ≥18 | CAP | S, SS, SSH | PCR | Yes | Yes | No | Yes | | Song et al. [39] | China | Asian | ≥18 | Sepsis | S, SS | PCR | No | Yes | No | Yes | | Azevedo et al. [40] | Brazil | Mixed | <18 | ICU | S, SS, SSH | PCR-RFLP | Yes | No | No | Yes | | Baghel et al. [41] | Indian | Asian | >18 | Surgery | S | PCR | Yes | Yes | No | Yes | | Montoya-Ruiz et al. [42] | American | Caucasian | >18 | Emergency | S | PCR | Yes | Yes | No | Yes |
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S: sepsis; SS: severe sepsis; SSH: septic shock; NA: not available; HEW: Hardy-Weinberg equilibrium; PCR: Polymerase chain reaction; PCR-RFLP: Polymerase Chain Reaction-Restriction Fragment Length Polymorphism; BM: blind method.
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