Hepatic Polarization Accelerated by Mechanical Compaction Involves HNF4α Activation

Figure 7

Disruption of F-actin polymerization and E-cadherin-mediated cell adherent junctions partially weakens primary hepatocyte functions triggered by mechanical compaction. (a–h) The levels of albumin and urea production in primary hepatocytes exposed to LatB or SHE78-7 and stimulated by 500 ×  were lower than those in cells stimulated by 500 ×  and untreated with LatB or SHE78-7 but still higher than those in cells just stimulated by 0 ×  (two-way ANOVA analysis and Bonferroni post-tests, ^&LatB or SHE78-7-treated vs. 0 g, ^#LatB or SHE78-7-treated vs. 500 g, , , , ).

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