Kupffer Cell-Derived TNF-α Triggers the Apoptosis of Hepatic Stellate Cells through TNF-R1/Caspase 8 due to ER Stress
ER stress in KCs decreased the levels of liver function markers and the degree of liver fibrosis in a rat model. (a) The serum levels of AST and ALT in each group. (b) The liver weight and liver indexes in each group. (c) The liver fibrosis in each group was detected by Sirius Red staining. (d) The α-SMA expression in each group was detected by immunohistochemical staining. (e) The collagen I and α-SMA expression in each group was detected by Western blot. (f) Quantitative analysis of Western blots. Model group vs. control group. #ER stress group vs. model group. ER stress group vs. depletion group, .
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