Research Article

Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents

Table 3

Threshold effect analysis of the association between the IGF-1 SDS and BA-CA before and after GH therapy by multivariate piecewise regression.

Inflection point of IGF-1 SDSBA-CA
(95% CI)

Baseline ()
 >-20.17 (0.08, 0.27)<0.001
 ≤-20.07 (-0.12, 0.26)0.454
Follow-up ()
 <20.20 (0.12, 0.28)<0.001
 ≥2-0.03 (-0.33, 0.27)0.866

Adjustment variables: age, sex, pubertal stage, height SDS, weight, BMI SDS, E2, T, LH, and FSH. Height SDS: height standard deviation scores; BMI SDS: body mass index standard deviation scores; E2: estradiol; T: testosterone; FSH: follicle stimulating hormone; LH: luteinizing hormone. is considered to be statistically significant.