Platelet-Rich Plasma Combined with Alendronate Reduces Pain and Inflammation in Induced Osteoarthritis in Rats by Inhibiting the Nuclear Factor-Kappa B Signaling Pathway
PRP combined with ALN inhibited the expression of inflammatory factors and improved cartilage matrix metabolism in osteoarthritis (OA) rats. The mRNA expression of IL-1β (a), IL-18 (b), TNF-α (c), Collagen II (d), and MMP-13 (e) in cartilage of rats was determined by qRT-PCR. compared with the Control group. # and ## compared with the OA group. && compared with the ALN group. $ and $$ compared with the PRP group.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.