Platelet-Rich Plasma Combined with Alendronate Reduces Pain and Inflammation in Induced Osteoarthritis in Rats by Inhibiting the Nuclear Factor-Kappa B Signaling Pathway
PRP combined with ALN promoted cell proliferation, improved cartilage matrix metabolism, and inhibited NF-κB signaling pathway in rat chondrocytes. (a) The proliferation of rat chondrocytes was detected by MTT assay. (b, c) The mRNA expression of Collagen II and MMP-13 in the rat chondrocytes was determined by qRT-PCR. (d) The protein expression of NF-κB signaling pathway-related proteins (p-p65, p65, IκBα, and p-IκBα) in the rat chondrocytes was determined by Western blot. and compared with the Control group. ## and # compared with the OA group. && compared with the ALN group. $ and $$ compared with the PRP group.
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