Platelet-Rich Plasma Combined with Alendronate Reduces Pain and Inflammation in Induced Osteoarthritis in Rats by Inhibiting the Nuclear Factor-Kappa B Signaling Pathway
PRP combined with ALN promoted cell proliferation, inhibited apoptosis, and improved cartilage matrix metabolism via NF-κB signaling pathway in rat chondrocytes. (a) The protein expression of NF-κB signaling pathway-related proteins (p-p65, p65, IκBα, and p-IκBα) in rat chondrocytes was determined by Western blot. (b) The proliferation of rat chondrocytes was detected by MTT assay. (c, d) The mRNA expression of Collagen II and MMP-13 in the rat chondrocytes was determined by qRT-PCR. and compared with the IL-1β group. ## and # compared with the IL-1β + PMA group. & and && compared with the IL-1β + ALN + PMA group. $ and $$ compared with the IL-1β + PRP + PMA group.
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