Research Article

No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis

Table 3

Characteristics of cirrhotic patients with ischemic stroke and those without stroke after propensity score matching.

VariablesOverall ()Ischemic stroke ()No stroke () value

Age (years)59.68 (35.18-77.30)60.65 (38.72-77.30)58.44 (35.18-75.72)0.258
Gender (male)47 (83.9%)22 (78.6%)25 (89.3%)0.275
Systolic blood pressure (mmHg)125.00 (83.00-173.00)124.50 (90.00-173.00)126.50 (83.00-158.00)0.491
Diastolic blood pressure (mmHg)75.50 (44.00-108.00)72.00 (50.00-108.00)81.00 (44.00-107.00)0.161
Etiology of liver diseases
 Hepatitis B virus infection23 (41.1%)10 (35.7%)13 (46.4%)0.415
 Hepatitis C virus infection1 (1.8%)1 (3.6%)0 (0.0%)0.313
 Alcohol abuse35 (62.5%)18 (64.3%)17 (60.7%)0.783
 Drug related6 (10.7%)4 (14.3%)2 (7.1%)0.388
 Budd-Chiari syndrome0 (0.0%)0 (0.0%)0 (0.0%)NA
 Autoimmune liver diseases1 (1.8%)0 (0.0%)1 (3.6%)0.313
Clinical presentations at admission
 Hepatic encephalopathy2 (3.6%)1 (3.6%)1 (3.6%)1.000
 Acute gastrointestinal bleeding13 (23.2%)7 (25.0%)6 (21.4%)0.752
 Ascites (no/mild/moderate-severe)27 (48.2%)/14 (25.0%)/15 (26.8%)15 (53.6%)/6 (21.4%)/7 (25.0%)12 (42.9%)/8 (28.6%)/8 (28.6%)0.710
History
 History of venous thrombus0 (0.0%)0 (0.0%)0 (0.0%)NA
 History of hematological diseases1 (1.8%)1 (3.6%)0 (0.0%)0.313
 History of diabetes mellitus12 (21.4%)8 (28.6%)4 (14.3%)0.193
 History of arterial hypertension13 (23.2%)10 (35.7%)3 (10.7%)0.027
 History of smoking39 (69.6%)20 (71.4%)19 (67.9%)0.771
 History of cardiac diseases8 (14.3%)5 (17.9%)3 (10.7%)0.445
Laboratory tests
 Red blood cell (1012/L)3.52 (1.15-5.20)3.34 (1.15-5.20)3.69 (1.74-5.08)0.456
 Hemoglobin (g/L)109.00 (37.00-174.00)102.00 (37.00-174.00)110.50 (58.00-156.00)0.812
 White blood cell (109/L)4.25 (1.30-22.70)4.70 (1.30-22.70)4.05 (1.30-20.80)0.063
 Platelet (109/L)84.50 (37.00-423.00)88.00 (37.00-377.00)75.00 (37.00-423.00)0.961
 Total bilirubin (μmol/L)24.25 (5.70-132.70)25.30 (5.70-132.70)24.15 (6.60-47.00)0.718
 Direct bilirubin (μmol/L)9.55 (2.00-78.20)9.30 (2.00-78.20)9.60 (2.50-27.00)0.961
 Indirect bilirubin (μmol/L)12.45 (3.60-76.00)12.60 (3.60-76.00)12.35 (4.10-27.70)0.967
 Albumin (g/L)32.55 (22.10-46.20)30.75 (22.10-44.50)33.95 (24.50-46.20)0.201
 Alanine aminotransferase (U/L)24.79 (7.53-176.68)21.66 (7.74-176.68)25.59 (7.53-140.00)0.793
 Aspartate aminotransferase (U/L)33.94 (9.74-166.49)34.22 (9.74-143.00)33.94 (13.94-166.49)0.857
 Alkaline phosphatase (U/L)98.86 (28.83-337.00)93.60 (28.83-337.00)102.83 (52.28-337.00)0.481
γ-Glutamyl transpeptidase (U/L)60.87 (10.00-1779.18)69.50 (10.00-1779.18)56.00 (10.93-552.26)0.611
 Blood urea nitrogen (mmol/L)5.62 (2.96-47.25)5.81 (3.52-47.25)5.38 (2.96-20.15)0.502
 Serum creatinine (μmol/L)66.64 (42.82-267.63)68.96 (42.82-267.63)64.19 (44.50-117.53)0.870
 Potassium (mmol/L)3.99 (2.74-5.41)4.03 (2.80-5.41)3.89 (2.74-4.75)0.517
 Sodium (mmol/L)138.50 (133.50-145.50)137.95 (134.10-145.50)139.65 (133.50-145.20)0.210
 Prothrombin time (seconds)15.30 (12.70-20.40)15.30 (12.70-20.40)15.25 (12.00-18.90)0.774
 International normalized ratio1.24 (0.93-1.75)1.24 (0.99-1.75)1.24 (0.93-1.64)0.883
 Activated partial thromboplastin time (seconds)40.10 (19.80-53.80)40.10 (19.80-53.80)40.30 (27.50-50.80)0.961
Child-Pugh score7.00 (5.00-10.00)7.00 (5.00-10.00)7.00 (5.00-13.00)0.259
MELD score10.43 (6.43-18.00)10.52 (7.23-18.00)10.32 (6.43-15.58)0.676
Portal vein thrombosis14 (25.0%)7 (25.0%)7 (25.0%)1.000

MELD: model for the end-stage liver diseases.