Research Article
Toxicokinetics of 11 Gelsemium Alkaloids in Rats by UPLC-MS/MS
Table 5
Toxicokinetic parameters of 11 Gelsemium alkaloids after intravenous administration in rats (0.1âmg/kg for each alkaloid).
| | Compound | AUC(0-) | AUC(0-â) | MRT(0-) | MRT(0-â) | | | | | | | h | h | h | L/kg | L/h/kg | ng/mL |
| | Humantenirine | | | | | | | | | | Humantenine | | | | | | | | | | Akuammidine | | | | | | | | | | Gelsevirine | | | | | | | | | | Rankinidine | | | | | | | | | | n-Methoxyanhydrovobasinediol | | | | | | | | | | Gelsenicine | | | | | | | | | | Gelsemine | | | | | | | | | | Koumine | | | | | | | | | | Koumidine | | | | | | | | | | Sempervirine | | | | | | | | |
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