TY - JOUR A2 - Raju, Nagarajan AU - Hassan, Iftekhar AU - Ebaid, Hossam AU - Alhazza, Ibrahim M. AU - Al-Tamimi, Jameel PY - 2020 DA - 2020/07/31 TI - The Alleviative Effect of Vitamin B2 on Potassium Bromate-Induced Hepatotoxicity in Male Rats SP - 8274261 VL - 2020 AB - Potassium bromate (PB) is a food enhancer, water disinfection by-product, and a proven carcinogen. It elicits toxicities in the living organism due to exposure and in a dose-dependent manner. The present study discourses the ameliorative efficacy of riboflavin (RF) in PB-administered rodents. The animals were distributed into five treatment groups: control (group I), PB alone (group II, 150 mg/kg), RF alone (group III, 2 mg/kg), PB+RF1 (group IV, 150mg/kg+2mg/kg), and PB+RF2 (group V, 150mg/kg+4mg/kg). After the round of the treatment, the animals were sacrificed to collect their blood and liver samples for the detailed analysis. Group II depicted perturbed liver functions evidenced by altered serum and toxicity markers along with the disturbed redox balance. Also, these biochemical results were found harmonious with histopathological analysis and comet assay. However, group III showed no noticeable alteration in the same parameters, whereas the combination groups (IV and V) exhibited dose-dependent amelioration in the PB-induced toxicities. Interestingly, RF favored apoptosis concomitant with suppressing the necrosis in the PB-challenged groups, as shown by the activity of caspase-3 and lactate dehydrogenase. Histopathological analysis and comet assay further consolidate these results. Hence, RF has significant alleviative property against PB-induced hepatotoxicity in vivo that can be used in the consumer items containing the toxicant. SN - 2314-6133 UR - https://doi.org/10.1155/2020/8274261 DO - 10.1155/2020/8274261 JF - BioMed Research International PB - Hindawi KW - ER -