The Alleviative Effect of Vitamin B₂ on Potassium Bromate-Induced Hepatotoxicity in Male Rats

Figure 7

Representative photomicrographs showing the liver tissue section from (a) control without any treatment (group I), (b) riboflavin-supplemented group (group III), (c, d) PB-challenged group (group II), (e, f) PB-challenged and treated with riboflavin at the dose of 2 mg/kg group (group IV), and (g, h) PB-challenged and treated with riboflavin at the dose of 4 mg/kg group (group V). Examined sections show that PB induced severe damage to the hepatic tissue pattern. Narrow blood sinusoids (green arrows) with vacuolated hepatocytes (red arrows) were remarkably observed. The liver tissues were infiltrated with inflammatory cells (yellow arrows), especially around the central vein, which was found with severe dilatation in comparison with the control one. A marked improvement was observed in PB-challenged rats treated with riboflavin (group IV) (e, f). This improvement was dose-dependent since 4 mg of riboflavin (g, h) was found to remarkably restore a hepatic pattern close to that of the control liver tissue. All rat sections were stained with H&E and photographed at a magnification of ×400.

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