The Alleviative Effect of Vitamin B₂ on Potassium Bromate-Induced Hepatotoxicity in Male Rats

Table 1

A rating between − (no change) and +++ (severe damage) of the histopathological alterations into the hepatic tissues. The score was assigned for each investigated section of all the groups. Sections from at least five rats were carefully investigated.

Treatment groups	Control (group I)	Potassium bromate (group II)	Riboflavin (group III)	Potassium bromate+riboflavin dose I (group IV)	Potassium bromate+riboflavin dose II (group V)
Dilated central vein	(−)	(+++)	(−)	(++)	(+)
Abundance of Kupffer cells	(−)	(+)	(−)	(++)	(+++)
Vacuolated hepatocyte cytoplasm	(−)	(+++)	(+)	(++)	(−)
Hyaline and eosinophilic hepatocyte cytoplasm	(−)	(−)	(−)	(−)	(+)
Degenerated hepatocyte nuclei	(−)	(+++)	(−)	(++)	(+)
Unclear boundaries of hepatocytes	(-)	(++)	(+)	(++)	(+)
Hemolysed blood	(−)	(+)	(−)	(+)	(−)
Narrow sinusoids	(−)	(+++)	(+)	(++)	(+)
Infiltrated tissue with inflammatory cells	(−)	(+++)	(+)	(++)	(+)