Research Article
NOTCH3 T6746C and TP53 P72R Polymorphisms Are Associated with the Susceptibility to Diffuse Cutaneous Systemic Sclerosis
Table 4
The comparison of NOTCH3 and TP53 allele frequencies among SSc patients and controls. The impact of studied polymorphisms on the risk of SSc.
| | Alleles | SSc cases, n = 248 (%) | Controls, n = 200 (%) | p values |
| | NOTCH3 | | | | | | | T | 216 (87%) | 164 (82%) | 0.13 | | C | 32 (13%) | 36 (18%) | | | Total: | 248 (100%) | 200 (100%) | — | | TP53 | | | | | | | R | 191 (77%) | 153 (76.5%) | 0.88 | | | | P | 57 (23%) | 47 (23.5%) | | | | | Total: | 248 (100%) | 200 (100%) | — |
| | Genotypes | SSc patients n = 124 (%) | Controls n = 100 (%) | OR | 95% CI | value |
| | NOTCH3 | | | | | | | TT | 97 (78%) | 66 (66%) | Reference | — | — | | CT + CC | 27 (22%) | 34 (34%) | 1.85 | 1.02–3.35 | 0.04 | | | lcSSc n = 101 (%) | Controls n = 100 (%) | | | TT | 77 (76%) | 66 (66%) | Reference | — | — | | CT + CC | 24 (24%) | 34 (34%) | 1.65 | 0.89–3.06 | 0.10 | | | dcSSC n = 23 (%) | Controls n = 100 (%) | | | TT | 20 (87%) | 66 (66%) | Reference | — | — | | CT + CC | 3 (13%) | 34 (34%) | 3.43 | 0.95–12.37 | 0.04 | | TP53 | | | | | | | RR | 72 (58%) | 59 (59%) | Reference | — | — | | PR + PP | 52 (42%) | 41 (41%) | 0.96 | 0.56–1.64 | 0.88 | | | lcSSc n = 101 (%) | Controls n = 100 (%) | | | RR | 53 (52%) | 59 (59%) | Reference | — | — | | PR + PP | 48 (48%) | 41 (41%) | 0.76 | 0.43–1.34 | 0.35 | | | dcSSC n = 23 (%) | Controls n = 100 (%) | | | RR | 19 | 59 (59%) | Reference | — | — | | PR + PP | 4 | 41 (41%) | 3.30 | 1.04–10.41 | 0.034 |
|
|
