Advanced Glycation End Products Induce Proliferation and Migration of Human Aortic Smooth Muscle Cells through PI3K/AKT Pathway
Phosphorylation of AKT induced by AGEs. (a) AGE (20 mg/L) treatment of cells significantly increased phosphorylation of AKT levels at 5 min to 15 min compared to control cells ( in each group). (b) p-AKT induced by AGEs was inhibited by LY294002 (PI3K inhibitor) ( in each group). was defined as significant difference.
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