Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol. ex. Maton in Rats
Table 4
Mean of the weight gain () weekly of group rats which received polyherbal formulation or control for 13 weeks in 91 days in the subchronic oral toxicity study.
Group and dose ()
Weight gain (g) weekly
1
2
3
4
5
6
7
8
9
10
11
12
13
Male
I (252 mg/kg)
Mean
12.90
2.40
12.40
14.40
8.90
13.10
10.40
4.80
4.40
6.20
6.80
2.40
2.30
SD
6.31
12.14
4.50
7.06
2.77
18.37
11.92
1.99
2.72
1.14
1.32
0.70
1.16
0.591
0.007
0.815
0.303
0.286
0.060
0.380
0.064
0.305
0.025
0.0001
0.0001
0.137
II (1,008 mg/kg)
Mean
-4.30
27.10
13.90
14.50
5.00
5.10
8.30
4.60
3.80
5.20
6.00
2.40
3.40
SD
6.38
8.66
11.25
6.29
2.67
0.88
5.77
2.63
2.30
0.42
1.05
1.17
1.26
0.048
0.022
0.988
0.291
0.128
1.000
0.825
0.040
0.105
1.000
0.0001
0.0001
0.390
III (4,032 mg/kg)
Mean
17.90
22.10
7.50
2.10
4.80
5.20
9.20
4.40
4.70
5.30
3.00
4.00
2.20
SD
18.38
13.47
27.35
12.06
2.15
0.79
4.34
1.96
1.16
1.25
0.94
1.33
0.79
0.204
0.195
0.346
0.037
0.099
0.981
0.615
0.024
0.471
0.816
0.546
0.024
0.091
IV (water, control)
Mean
9.30
15.90
14.00
10.40
7.30
5.10
7.60
6.50
5.40
5.20
3.30
5.30
3.00
SD
21.57
6.03
5.56
7.59
4.92
0.74
2.07
1.08
2.12
0.79
1.06
1.57
0.82
Female
I (252 mg/kg)
Mean
5.36
-4.50
2.50
6.20
8.10
7.10
3.80
7.50
5.80
5.50
5.90
2.60
3.30
SD
6.84
6.82
12.31
15.50
4.28
1.79
13.20
3.10
1.32
1.18
0.99
0.97
1.49
0.0001
0.173
0.006
0.141
0.016
0.082
0.326
0.317
0.873
0.206
0.0001
0.031
0.069
II (1,008 mg/kg)
Mean
-10.48
5.90
4.20
9.20
5.20
6.20
7.00
8.80
6.00
5.60
6.40
3.40
4.00
SD
5.44
3.51
5.73
3.88
1.03
1.14
1.89
2.30
1.76
1.51
0.84
0.97
1.56
0.705
0.100
0.020
0.033
0.852
0.859
0.975
0.025
0.873
0.267
0.0001
0.344
0.003
III (4,032 mg/kg)
Mean
-3.81
2.40
3.70
6.80
6.40
5.10
6.00
5.40
5.30
5.60
3.30
3.80
2.90
SD
15.48
8.34
5.23
1.81
1.26
0.99
3.68
1.90
1.34
1.51
1.06
1.87
0.88
0.061
0.511
0.014
0.108
0.353
0.082
0.774
0.272
0.206
0.267
0.650
0.751
0.208
IV (water, control)
Mean
-12.12
0.20
12.30
-0.20
5.40
6.10
6.90
6.50
5.40
6.30
3.10
4.00
2.30
SD
7.18
10.00
3.13
10.11
1.26
0.88
1.66
0.97
0.97
1.34
0.99
1.56
0.48
, the significant difference compared to the control group using the one-way ANOVA continued by Tukey’s multiple comparison test.
