Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol. ex. Maton in Rats
Table 5
Mean of the food intake () weekly of group rats which received polyherbal formulation or control for 13 weeks in 91 days in the subchronic oral toxicity study.
Group and dose ()
Food intake (g) weekly
1
2
3
4
5
6
7
8
9
10
11
12
13
Male
I (252 mg/kg)
Mean
76.50
85.00
86.00
110.00
109.00
95.00
108.00
112.00
116.00
120.00
116.50
118.00
117.50
SD
6.69
5.27
5.16
9.43
5.68
5.27
7.53
5.87
4.59
0.00
4.12
4.22
4.25
0.213
0.0001
0.267
0.777
0.518
0.0001
0.0001
0.129
0.820
0.0001
0.133
0.428
1.000
II (1,008 mg/kg)
Mean
75.50
76.00
86.00
87.00
96.00
101.00
104.00
107.00
110.00
120.00
118.00
120.00
118.50
SD
4.38
4.59
5.16
4.22
6.99
4.59
3.94
5.37
4.08
0.00
2.58
0.00
2.42
0.100
0.163
0.267
0.0001
0.001
0.207
0.0001
0.001
0.005
0.0001
0.703
0.021
0.496
III (4,032 mg/kg)
Mean
77.50
75.00
86.50
108.00
108.50
106.00
113.00
115.50
118.00
119.00
119.0
117.00
116.50
SD
5.89
5.27
4.74
7.89
7.47
3.94
6.75
4.97
6.32
2.11
2.11
2.58
3.37
0.404
0.349
0.373
0.398
0.028
0.207
0.033
1.000
0.495
0.003
0.703
1.000
0.496
IV (water, control)
Mean
79.50
73.00
88.50
111.00
107.00
103.50
118.50
115.50
116.50
115.50
118.50
117.00
117.50
SD
3.69
3.50
4.74
8.76
7.15
3.37
2.42
3.69
4.12
4.38
2.42
2.58
2.64
Female
I (252 mg/kg)
Mean
76.00
86.00
84.00
116.00
114.00
95.00
108.00
114.00
119.00
118.50
115.00
120.50
117.00
SD
5.68
5.16
5.16
5.16
6.99
5.27
6.75
4.59
6.15
2.42
4.08
3.69
2.58
0.844
0.0001
0.445
0.152
0.771
0.041
0.003
0.0001
0.0001
0.590
0.044
0.068
1.000
II (1,008 mg/kg)
Mean
79.00
75.00
81.50
84.00
90.00
120.50
109.00
114.50
117.00
120.00
120.00
117.50
118.00
SD
6.58
5.27
6.69
4.59
9.43
39.33
3.16
2.84
3.50
0.00
0.00
4.25
2.58
0.328
0.656
0.091
0.0001
0.0001
0.472
0.011
0.0001
0.001
0.285
0.172
1.000
0.404
III (4,032 mg/kg)
Mean
77.00
72.00
85.50
106.50
108.00
103.00
116.00
117.50
119.50
118.00
117.00
117.00
114.50
SD
5.87
4.22
5.99
6.69
7.89
2.58
4.59
3.54
3.69
2.58
4.22
3.50
2.84
0.844
0.080
0.848
0.052
0.048
0.227
0.656
0.0001
0.0001
0.285
0.490
0.756
0.042
IV (water, control)
Mean
76.50
76.00
86.00
112.00
115.00
114.00
115.00
106.50
110.00
119.00
118.00
117.50
117.00
SD
4.12
5.16
5.16
7.53
5.77
4.59
4.71
3.37
3.33
2.11
2.58
2.64
2.58
, the significant difference compared to the control group using the one-way ANOVA continued by Tukey’s multiple comparison test.
