The Utility of Diffusion and Perfusion Magnetic Resonance Imaging in Target Delineation of High-Grade Gliomas

Table 1

Clinical characteristics. Comparison of the baseline characteristics of the patients for which multimodality MRI or CE-MRI alone helped to define the postoperative radiotherapy target volumes.

Characteristic	All patients () no. (%)	Multimodality MRI () no. (%)	CE-MRI () no. (%)	value
Age (years)				0.92
Median	50	51	49.5
Range	7-75	7-75	8-72
Age				0.99
≤50	49 (48)	24 (48)	25 (48)
>50	53 (52)	26 (52)	27 (52)
Gender				0.88
Male	66 (65)	32 (64)	34 (65)
Female	36 (35)	18 (36)	18 (35)
WHO grade				0.38
III	37 (36)	16 (32)	21 (40)
IV	65 (64)	34 (68)	31 (60)
Combined with epilepsy				0.53
Yes	16 (16)	9 (18)	7 (13)
No	86 (84)	41 (82)	45 (87)
Mental functions				0.93
Normal	84 (82)	41 (82)	43 (83)
Dysfunction	18 (18)	9 (18)	9 (17)
Extent of surgery				0.51
Complete resection	40 (39)	18 (36)	22 (42)
Partial resection	62 (61)	32 (64)	30 (58)
Interval between surgery and radiotherapy (wk)				0.96
Median	4	4	4
Range	2-8	3-8	2-8
Radiotherapy
Dose (Gy)				0.98
Median	60	60	60
Range	45-72	46-72	45-70
Dose				0.37
≥60Gy	91 (89)	46 (92)	45 (87)
<60Gy	11 (11)	4 (8)	7 (13)
Fractions				0.71
Median	30	30	30
Range	17-48	17-48	20-45
Concomitant temozolomide	102 (100)	50	52
Adjuvant-therapy				0.49
Adjuvant temozolomide	23 (23)	12 (24)	11 (21)
Targeted therapy	17 (17)	7 (14)	10 (19)