Predicting the Clinical Outcome of Lung Adenocarcinoma Using a Novel Gene Pair Signature Related to RNA-Binding Protein

Table 2

Summary of the results of univariate and multivariate analyses of the risk factors for the overall survival of patients with lung adenocarcinoma in TCGA cohort and the GEO cohort.

Datasets	Variables	Univariate analysis		Multivariate analysis
		HR (95% CI)	value	HR (95% CI)	value
TCGA (exploratory dataset)	Age	0.997 (0.978−1.015)	0.718	1.008 (0.989−1.028)	0.402
	Gender	1.000 (0.694−1.441)	1.000	0.980 (0.673−1.428)	0.917
	Stage	1.648 (1.396−1.946)	<0.001	2.119 (1.250-3.590)	0.005
	T stage	1.600 (1.285−1.994)	<0.001	1.083 (0.835-1.404)	0.549
	M stage	1.748 (0.959−3.187)	0.068	0.272 (0.071-1.039)	0.057
	N stage	1.787 (1.455−2.195)	<0.001	0.759 (0.472-1.233)	0.258
	Risk-score	3.967 (3.068−5.131)	<0.001	3.666 (2.791−4.815)	<0.001
GSE72094 (validation dataset)	Age	1.008 (0.985-1.031)	0.517	1.004 (0.980-1.028)	0.754
	Gender	1.885 (1.223-2.905)	0.004	2.205 (1.417-3.430)	<0.001
	Smoking	1.261 (0.549-2.897)	0.584	0.904 (0.390-2.095)	0.815
	Stage	1.704 (1.393-2.083)	<0.001	1.855 (1.499-2.297)	<0.001
	Risk-score	2.202 (1.525-3.179)	<0.001	2.214 (1.533-3.198)	<0.001

Abbreviations: HR: hazard ratio; CI: confidence interval.