Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia
Table 1
Distribution of HIV-infected individuals involved in the study by age, sex, routes of infection, and a possible period of infection with the indication of the detected HIV-1 genetic variants.
Total number of patients (%)
HIV-1 genotype†
value
A6
CRF63_02A1
CRF02_AG
URF63/A
URFA/B
URF02/A
Age (years)
20–39
113 (71.1)
63 (55.8)
15 (13.3)
1 (0.9)
28 (24.8)
5 (4.4)
1 (0.9)
0.985
40–49
41 (25.8)
24 (58.5)
5 (12.2)
0
9 (22.0)
2 (4.9)
1 (2.4)
≥50
5 (3.1)
4 (80.0)
0
0
1 (20.0)
0
0
Gender
Female
75 (47.2)
42 (56.0)
10 (13.3)
0
17 (22.7)
5 (6.7)
1 (1.3)
0.8
Male
84 (52.8)
49 (58.3)
10 (11.9)
1 (1.2)
21 (25)
2 (2.4)
1 (1.2)
Route of infection
Heterosexual
67 (42.1)
42 (62.7)
8 (11.9)
0
13 (19.4)
3 (4.5)
1 (1.5)
0.541††
Heterosexual with PWID
10 (6.3)
4 (40.0)
3 (30.0)
0
2 (20.0)
1 (10.0)
0
PWID
75 (47.2)
43 (57.3)
7 (9.3)
1 (1.3)
20 (26.7)
3 (4.0)
1 (1.3)
Homosexual
1 (0.6)
0
0
0
1 (100.0)
0
0
Not available
6 (3.8)
2 (33.3)
2 (33.3)
0
2 (33.3)
0
0
Diagnosis period
1999–2008
17 (10.7)
15 (88.2)
0
1 (5.9)
0
0
1 (5.9)
0.005
2009–2012
20 (12.6)
18 (90.0)
2 (10.0)
0
0
0
0
2013–2014
21 (13.2)
12 (57.1)
3 (9.5)
0
6 (28.6)
1 (4.8)
0
2015–2017
101 (63.5)
46 (45.5)
15 (15.8)
0
32 (31.7)
6 (5.9)
1 (1)
1999–2017
159 (100)
91 (57.2)
20 (12.6)
1 (0.6)
38 (23.9)
7 (4.4)
2 (1.3)
†HIV-1 genotype: the result of HIV-1 genotyping obtained after analysis of the complex of data: phylogenetic analysis from RP-RT, IN, and env regions and additional recombination analysis in case of inconsistency of genotyping results; ††gradation “homosexual contacts” was excluded from the analysis due to a low number of observations; . PWID: people who inject drugs.
