Pharmacokinetic Effects of l-Tetrahydropalmatine on Ketamine in Rat Plasma by Ultraperformance Liquid Chromatography Tandem Mass Spectrometry

Table 5

Pharmacokinetic parameters of KET after administration of KET alone and in combination with L-THP ().

Parameters	Unit	KET group	Parameters	Unit	KET+L-THP group
AUC0-∞	μg·min/mL		AUC0-∞	μg·min/mL
	min			min
CL	L/h/kg			min
	μg/mL		CL	L/h/kg
	min			μg/mL
		—		min
		—		min

Values represent the of six rats/group. Through gastric gavage, rats were administered KET alone (100 mg/kg) or in combination with oral L-THP (40 mg/kg). Significantly different from KET-treated rats ().