Pharmacokinetic Effects of l-Tetrahydropalmatine on Ketamine in Rat Plasma by Ultraperformance Liquid Chromatography Tandem Mass Spectrometry

Table 6

Pharmacokinetic parameters of NK after administration of KET alone and in combination with L-THP ().

Parameters	Unit	KET group	KET+L-THP group
AUC	μg·min/mL
	Min^-1
CL	L·kg/h
	μg/mL

Values represent the of six rats/group. Rats were treated with oral KET (100 mg/kg) alone or in combination with L-THP p.o. (40 mg/kg). Significantly different from KET-treated rats ().