UL16-Binding Protein 1 Induced HTR-8/SVneo Autophagy via NF-κB Suppression Mediated by TNF-α Secreted through uNK Cells

Figure 2

TNF-α-induced HTR-8/SVneo cell autophagy in a dose-dependent way via suppressing NF-κB activity. (a, b) The expression of LC3-II/I was significantly increased and P62 was significantly decreased within a high dose of TNF-α (every two groups have significant difference). (c) NF-κB inhibitor PDTC significantly increased the TNF-α-induced autophagy (every two groups have significant differences). (d) Representative images of HTR-8/SVneo cells in different condition media observed by TEM. Arrows indicate the autophagosome. (e) Autophagic activities were observed using a fluorescence microscope.

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