Research Article
The Value of Next-Generation Sequencing for Treatment in Non-Small Cell Lung Cancer Patients: The Observational, Real-World Evidence in China
Table 1
Association between clinicopathological features and EGFR mutations in NSCLC patients.
| | Characteristics | All (%) | EGFR 19 del | value | EGFR L858R | value | | Wide-type (%) | Mutant (%) | Wide-type (%) | Mutant (%) |
| | Age (years) | | | | 0.161 | | | 0.422 | | ≥65 | 29 (43.94) | 24 (48.98) | 5 (29.41) | | 22 (41.51) | 7 (53.85) | | | <65 | 37 (56.06) | 25 (51.02) | 12 (70.59) | | 31 (58.49) | 6 (46.15) | |
| | Sex | | | | 0.045 | | | 0.858 | | Male | 37 (56.06) | 31 (63.27) | 6 (35.29) | | 30 (56.60) | 7 (53.85) | | | Female | 29 (43.94) | 18 (36.73) | 11 (64.71) | | 23 (43.40) | 6 (46.15) | |
| | Smoking history | | | | 0.041 | | | 0.548 | | No | 26 (39.39) | 15 (30.61) | 11 (64.71) | | 21 (39.62) | 5 (38.46) | | | Yes | 38 (57.58) | 32 (65.31) | 6 (35.29) | | 31 (58.49) | 7 (53.85) | | | Unknown | 2 (3.03) | 2 (4.08) | 0 | | 1 (1.89) | 1 (7.69) | |
| | Family history | | | | 0.016 | | | 0.340 | | No | 43 (65.15) | 36 (73.47) | 7 (41.18) | | 36 (22.03) | 7 (53.85) | | | Yes | 23 (34.85) | 13 (26.53) | 10 (58.82) | | 17 (77.97) | 6 (46.15) | |
| | Pathological type | | | | 0.032 | | | 0.333 | | Adenocarcinoma | 55 (83.33) | 38 (77.55) | 17 (100) | | 43 (81.13) | 12 (92.31) | | | Squamous cell carcinoma | 11 (16.67) | 11 (22.45) | 0 | | 10 (18.87) | 1 (7.69) | |
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EGFR 19-del mutation had an increased frequency in female ( ), non-smokers( ), who had family history ( ) and adenocarcinoma patients ( ). |
