Integrative Analysis of MAPK14 as a Potential Biomarker for Cardioembolic Stroke

Table 1

The top 20 genes in the PPI network of coexpressed differentially expressed genes were identified by using the five algorithms in cytoHubba. MCC: maximal clique centrality; MNC: maximum neighborhood component; EPC: edge percolated component.

Gene name	MCC	Gene name	MNC	Gene name	Degree	Gene name	EPC	Gene name	Closeness
STAT3	1087	MMP9	22	STAT3	26	MMP9	62.732	STAT3	78.1
MMP9	1011	STAT3	21	MMP9	23	STAT3	62.774	MMP9	75.65
CTNNB1	992	CTNNB1	16	CTNNB1	20	CTNNB1	61.907	CTNNB1	73.06667
ESR1	922	MAPK14	13	MAPK14	19	MAPK14	61.571	MAPK14	72.31667
MAPK14	908	SOX9	13	ESR1	16	SOX9	61.536	ESR1	70.43333
SP1	877	ESR1	12	SOX9	15	ESR1	60.606	SOX9	68.06667
SOX9	782	HGF	12	HGF	15	HGF	60.445	SP1	67.35
CD59	735	TLR5	12	SP1	14	TLR5	58.117	MDM2	67.11667
CKAP4	733	SP1	11	TLR5	13	SP1	59.583	HGF	66.31667
CLEC4D	728	THBS1	11	CD59	13	THBS1	58.92	TLR5	64.01667
FCAR	722	CD59	10	MDM2	13	CD59	53.507	THBS1	63.13333
CLEC5A	722	CD163	10	THBS1	12	CD163	55.975	CD163	61.26667
GPR97	720	CKAP4	9	CD19	12	CKAP4	52.89	TJP1	60.9
MCEMP1	720	TIMP2	9	CLEC4D	11	TIMP2	55.794	VIM	60.86667
HGF	159	MDM2	8	CD163	10	MDM2	57.54	CD19	60.75
MDM2	153	CLEC7A	8	CKAP4	10	CLEC7A	53.965	FGF13	60.48333
THBS1	127	FGF13	8	VCAN	10	FGF13	57.717	TXN	60.18333
TLR5	103	ARG1	8	TJP1	10	ARG1	55.686	CLEC7A	59.38333
FGF13	103	SERPINA1	8	TIMP2	9	SERPINA1	54.683	ARG1	59.18333
TIMP2	72	VCAN	7	CLEC7A	9	VCAN	53.968	NOTCH2	58.98333