MicroRNA-148b Inhibits the Malignant Biological Behavior of Melanoma by Reducing Sirtuin 7 Expression Levels

Figure 2

Upregulated expression of SIRT7 in melanoma. (a) The expression levels of SIRT7 in melanoma tissues and benign nevi measured by immunofluorescence staining: A–E: melanoma; F and G: benign nevi; ×400 magnification. (b) The mRNA expression level of SIRT7 in benign nevus and melanoma tissues measured by RT-qPCR. (c) Heat map of top 50 differentially expressed genes in GSE98394 coloring the sample groups, the depth of color represents the expression value of the gene. (d) Relative expression of SIRT7 in normal and tumor group in GSE98394. Significant difference at .

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