Overexpression of miR-29a-3p Suppresses Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells in Atherosclerosis via Targeting TNFRSF1A

Figure 1

Overexpression of miR-29a-3p distinctly reduces aorta plaque formation for atherosclerosis (AS) mice. (a) Serum miR-29a-3p levels were examined in AS mice with or without miR-29a-3p mimic injection using RT-qPCR. (b, c) RT-qPCR was presented to detect miR-29a-3p as well as TNFRSF1A expression in AS mice with or without miR-29a-3p mimic injection. (d, e) TNFRSF1A protein expression was tested in AS mice with or without miR-29a-3p overexpression via western blot. (f–i) Biochemical test was performed to test the serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in AS mice with or without miR-29a-3p mimic injection. (j) Representative images of H&E staining for aorta of AS mice. (k) Representative images of Masson’s staining results for aorta of AS mice. ; ; .

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