Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway

Figure 2

Bmal1 deficiency increased cell apoptosis of INS-1 cells. INS-1 cells were incubated with or without Bmal1 inhibition. Apoptotic cells were detected by the tunel assay. Images were obtained at magnifications of 400x. The nucleus of normal cells was blue and of apoptotic cells was pink. NC: normal control group; siRNA-NC: INS-1 cells treated with negative control siRNA; siRNA-Bmal1: INS-1 cells treated with Bmal1 siRNA.

(a) NC

(b) siRNA-NC

(c) siRNA-Bmal1