Research Article
Prostate Health Index and Prostate Health Index Density as Diagnostic Tools for Improved Prostate Cancer Detection
Table 4
Sensitivity, specificity, and positive and negative predictive values of blood serum biomarkers in predicting
grade prostate cancer.
| | According to Youden’s index | 90% sensitivity | | Cut-off | Sensitivity (% (95% CI)) | Specificity (% (95% CI)) | PPV (% (95% CI)) | NPV (% (95% CI)) | Cut-off | Specificity (% (95% CI)) | PPV (% (95% CI)) | NPV (% (95% CI)) |
| | tPSA (ng/mL) | 4.48 | 47.5 (31.5-63.9) | 68.2 (60.7-75.2) | 26.0 (16.5-37.6) | 84.7 (77.5-90.3) | 2.50 | 10.6 (6.0-15.2) | 19.1 (13.5-24.8) | 81.8 (65.7-97.4) | | PSAD (ng/mL/cc) | 0.13 | 57.5 (40.9-73.0) | 77.6 (70.1-83.7) | 37.7 (25.6-51.0) | 88.6 (82.4-93.2) | 0.04 | 5.3 (2.5-9.8) | 19.1 (13.9-25.3) | 81.8 (48.2-97.7) | | fPSA (ng/mL) | 0.73 | 77.5 (61.6-89.2) | 34.1 (27.0-41.8) | 21.7 (15.2-29.3) | 86.6 (76.0-93.7) | 0.29 | 6.5 (2.8-10.2) | 18.5 (13.0-23.9) | 73.3 (51.0-95.7) | | %fPSA | 11.30-11.69 | 57.5 (40.9-73.0) | 78.8 (71.9-84.7) | 39.0 (26.6-52.6) | 88.7 (82.6-93.3) | 7.00 | 4.7 (1.5-7.9) | 17.8 (12.4-23.1) | 61.5 (35.1-88.0) | | p2PSA (pg/mL) | 26.11-30.29 | 7.5 (1.6-20.4) | 96.5 (92.5-98.7) | 33.3 (7.5-70.1) | 81.6 (75.5-86.7) | 6.21 | 8.8 (4.6-13.1) | 18.8 (13.3-24.4) | 78.9 (60.6-97.3) | | %p2PSA | 1.88 | 85.0 (70.2-94.3) | 47.6 (39.9-55.4) | 27.6 (20.0-36.4) | 93.1 (85.6-97.4) | 1.65 | 34.1 (27.0-41.2) | 24.3 (17.7-32.1) | 93.5 (87.4-100.0) | | phi | 44.71 | 75.0 (58.8-87.3) | 72.4 (65.0-78.9) | 39.0 (28.1-50.8) | 92.5 (86.6-96.3) | 33.20 | 34.7 (27.6-41.9) | 24.5 (17.54-31.4) | 93.7 (87.6-100.0) | | PHID | 1.04 | 75.0 (58.8-87.3) | 66.5 (58.8-73.5) | 34.5 (24.6-45.4) | 91.9 (85.6-96.0) | 0.63 | 34.1 (27.0-41.8) | 24.3 (17.4-31.2) | 93.5 (87.4-98.2) |
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Abbreviations: CI: confidence interval; fPSA: free prostate-specific antigen; ISUP: International Society of Urological Pathology; NPV: negative predictive value; PPV: positive predictive value; PSAD: prostate-specific antigen density; phi: Prostate Health Index; tPSA: total PSA; %fPSA: free to total PSA ratio; %p2PSA: p2PSA to fPSA ratio.
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