Bioinformatics Analysis of GFAP as a Potential Key Regulator in Different Immune Phenotypes of Prostate Cancer

Figure 2

Differences in MHC class I gene expression and somatic mutations between the two immune phenotypes. (a) The transcription levels for B2M and for human leukocyte antigen (HLA) genes encoding MHC class I protein in TCGA-PRAD (top) and ICGC-PRAD cohorts (bottom). (b) The top-10 mutated genes in groups (top) and (bottom) in thePRAD database. (c) In TCGA-PRAD cohort, the mutation frequency of TP53 in group was relatively higher than in group for most types of cancer.

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