Prevalence and Risk Factors for Adrenal Insufficiency in Patients with Multiple Myeloma Receiving Long-Term Chemotherapy including Corticosteroids: A Retrospective Cohort Study
Table 1
Baseline characteristics of patients with multiple myeloma according to the presence of adrenal insufficiency.
Variables
Overall ()
No-AI ()
AI ()
value
Age (years)
0.076
Sex (male)
148 (52.5)
75 (53.6)
73 (51.4)
0.716
BMI (kg/m2)
0.333
Comorbidities
Hypertension
135 (47.9)
73 (52.1)
62 (43.7)
0.154
Diabetes
91 (32.3)
46 (32.9)
45 (31.7)
0.834
CVD
33 (11.7)
18 (12.9)
15 (10.6)
0.549
CKD
115 (40.8)
58 (41.4)
57 (40.1)
0.826
Thromboembolism
25 (8.9)
11 (7.9)
14 (9.9)
0.554
Laboratory findings
WBC (×103/μL)
0.792
Hemoglobin (g/dL)
0.943
PLT (× 103/μL)
0.587
AST (IU/L)
0.223
ALT (IU/L)
0.106
Creatinine (mg/dL)
0.565
eGFR (mL/min/1.73 m2)
0.199
Total protein (g/dL)
0.672
Albumin (g/dL)
0.987
Sodium (mEq/L)
0.176
Calcium (ionized) (mEq/L)
0.765
Rapid ACTH stimulation test
ACTH (basal) (pg/mL)
37.0 (19.0–57.0)
43.5 (27.0–66.8)
26.9 (15.8–51.3)
<0.001
Cortisol (basal) (μg/dL)
<0.001
Cortisol (30 min) (μg/dL)
<0.001
Cortisol (60 min) (μg/dL)
<0.001
Data are presented as or median (interquartile range) or (%). AI: adrenal insufficiency; BMI: body mass index; CVD: cardiovascular disease; CKD: chronic kidney disease; WBC: white blood cell count; PLT: platelet; AST: aspartate aminotransferase; ALT: alanine aminotransferase; eGFR: estimated glomerular filtration rate; ACTH: adrenocorticotropic hormone.
