PTHR1 Genetic Polymorphisms Are Associated with Osteoporosis among Postmenopausal Arab Women
Table 2
Genotype and allele frequency distribution of PTH and PTHRs SNPs in the study groups.
Gene
SNP ID
Chromosome: position
Gen.
CG
PMO
Adjusted OR (95% CI)
Adjusted value
(%)
(%)
PTH
rs1459015
11 : 13500728
T/T
17 (5.9)
16 (5.6)
0.98 (0.48-1.98)
0.9
C/T
49 (17.0)
56 (19.6)
1.19 (0.77-1.82)
0.43
C/C
222 (77.1)
214 (74.8)
1
T
83 (14.4)
88 (15.4)
1.08 (0.78-1.49)
0.64
C
493 (85.6)
484 (84.6)
1
rs307253
11 : 13488070
A/A
36 (12.5)
40 (14.0)
1.05 (0.62-1.76)
0.87
A/G
110 (38.2)
106 (37.1)
0.91 (0.62-1.32)
0.60
G/G
110 (38.2)
117 (40.9)
1
A
182 (35.5)
186 (35.4)
0.99 (0.77-1.28)
0.95
G
330 (64.5)
340 (64.6)
1
rs307247
11 : 13491931
A/A
31 (10.8)
36 (12.6)
1.17 (0.68-2.1)
0.57
A/G
103 (35.8)
90 (31.5)
0.88 (0.6-1.3)
0.52
G/G
111 (38.5)
110 (38.5)
1
A
165 (33.7)
162 (34.3)
1.03 (0.79–1.34)
0.83
G
325 (66.3)
310 (65.7)
1
rs10500783
11 : 13552067
T/T
16 (5.6)
17 (5.9)
0.98 (0.48-2.0)
0.97
C/T
97 (33.7)
76 (26.6)
0.73 (0.51-1.04)
0.08
C/C
177 (61.5)
191 (66.8)
1
T
129 (22.2)
110 (19.4)
0.84 (0.63–1.12)
0.23
C
451 (77.8)
458 (80.6)
1
rs10500784
11 : 13552278
CC
16 (5.6)
15 (5.2)
0.86 (0.41-1.78)
0.68
A/C
97 (33.7)
75 (26.2)
0.71 (0.49-1.01)
0.06
AA
177 (61.5)
194 (67.8)
1
A
129 (22.2)
105 (18.5)
0.79 (0.59–1.06)
0.11
C
451 (77.8)
463 (81.5)
1
PTHR1
rs6442037
3 : 46888056
G/G
35 (12.2)
26 (9.1)
0.82 (0.47-1.43)
0.48
A/G
89 (30.9)
98 (34.3)
1.21 (0.83-1.75)
0.32
A/A
146 (50.7)
133 (46.5)
1
G
159 (29.4)
150 (29.2)
0.99 (0.76–1.29)
0.93
A
381 (70.6)
364 (70.8)
1
rs1138518
3 : 46902784
T/T
37 (12.8)
36 (12.6)
1.23 (0.73-2.10)
0.43
C/T
102 (35.4)
120 (42.0)
1.49 (1.04-2.14)
0.03
C/C
142 (49.3)
112 (39.2)
1
T
176 (31.3)
192 (35.8)
1.22 (0.95–1.57)
0.11
C
386 (68.7)
344 (64.2)
1
rs724449
3 : 46894191
T/T
72 (25.0)
70 (24.5)
1.02 (0.65-1.62)
0.92
C/T
101 (35.1)
119 (41.6)
1.24 (0.82-1.87)
0.30
C/C
79 (27.4)
75 (26.2)
1
T
245 (48.6)
259 (49.1)
1.02 (0.80–1.30)
0.89
C
259 (51.4)
269 (50.9)
1
PTHR2
rs9288393
2 : 208404685
G/G
29 (10.1)
30 (10.5)
0.96 (0.55-1.67)
0.88
C/G
106 (36.8)
92 (32.2)
0.81 (0.56-1.15)
0.23
C/C
154 (53.5)
166 (58.0)
1
G
164 (28.4)
152 (26.4)
0.91 (0.70–1.17)
0.45
C
414 (71.6)
424 (73.6)
1
Note: data presented (%). value significant at 0.05 and 0.01 level using multinomial logistic regression and chi-square test. Odds ratio (OR) and value adjusted for adjustment of multiple comparisons. Significant values are in bold text. Reference.