Research Article

PTHR1 Genetic Polymorphisms Are Associated with Osteoporosis among Postmenopausal Arab Women

Table 2

Genotype and allele frequency distribution of PTH and PTHRs SNPs in the study groups.

GeneSNP IDChromosome: positionGen.CGPMOAdjusted OR (95% CI)Adjusted value
(%) (%)

PTHrs145901511 : 13500728T/T17 (5.9)16 (5.6)0.98 (0.48-1.98)0.9
C/T49 (17.0)56 (19.6)1.19 (0.77-1.82)0.43
C/C222 (77.1)214 (74.8)1
T83 (14.4)88 (15.4)1.08 (0.78-1.49)0.64
C493 (85.6)484 (84.6)1
rs30725311 : 13488070A/A36 (12.5)40 (14.0)1.05 (0.62-1.76)0.87
A/G110 (38.2)106 (37.1)0.91 (0.62-1.32)0.60
G/G110 (38.2)117 (40.9)1
A182 (35.5)186 (35.4)0.99 (0.77-1.28)0.95
G330 (64.5)340 (64.6)1
rs30724711 : 13491931A/A31 (10.8)36 (12.6)1.17 (0.68-2.1)0.57
A/G103 (35.8)90 (31.5)0.88 (0.6-1.3)0.52
G/G111 (38.5)110 (38.5)1
A165 (33.7)162 (34.3)1.03 (0.79–1.34)0.83
G325 (66.3)310 (65.7)1
rs1050078311 : 13552067T/T16 (5.6)17 (5.9)0.98 (0.48-2.0)0.97
C/T97 (33.7)76 (26.6)0.73 (0.51-1.04)0.08
C/C177 (61.5)191 (66.8)1
T129 (22.2)110 (19.4)0.84 (0.63–1.12)0.23
C451 (77.8)458 (80.6)1
rs1050078411 : 13552278CC16 (5.6)15 (5.2)0.86 (0.41-1.78)0.68
A/C97 (33.7)75 (26.2)0.71 (0.49-1.01)0.06
AA177 (61.5)194 (67.8)1
A129 (22.2)105 (18.5)0.79 (0.59–1.06)0.11
C451 (77.8)463 (81.5)1

PTHR1rs64420373 : 46888056G/G35 (12.2)26 (9.1)0.82 (0.47-1.43)0.48
A/G89 (30.9)98 (34.3)1.21 (0.83-1.75)0.32
A/A146 (50.7)133 (46.5)1
G159 (29.4)150 (29.2)0.99 (0.76–1.29)0.93
A381 (70.6)364 (70.8)1
rs11385183 : 46902784T/T37 (12.8)36 (12.6)1.23 (0.73-2.10)0.43
C/T102 (35.4)120 (42.0)1.49 (1.04-2.14)0.03
C/C142 (49.3)112 (39.2)1
T176 (31.3)192 (35.8)1.22 (0.95–1.57)0.11
C386 (68.7)344 (64.2)1
rs7244493 : 46894191T/T72 (25.0)70 (24.5)1.02 (0.65-1.62)0.92
C/T101 (35.1)119 (41.6)1.24 (0.82-1.87)0.30
C/C79 (27.4)75 (26.2)1
T245 (48.6)259 (49.1)1.02 (0.80–1.30)0.89
C259 (51.4)269 (50.9)1

PTHR2rs92883932 : 208404685G/G29 (10.1)30 (10.5)0.96 (0.55-1.67)0.88
C/G106 (36.8)92 (32.2)0.81 (0.56-1.15)0.23
C/C154 (53.5)166 (58.0)1
G164 (28.4)152 (26.4)0.91 (0.70–1.17)0.45
C414 (71.6)424 (73.6)1

Note: data presented (%). value significant at 0.05 and 0.01 level using multinomial logistic regression and chi-square test. Odds ratio (OR) and value adjusted for adjustment of multiple comparisons. Significant values are in bold text. Reference.