Treatment with SCU, on the other hand, increases expression levels of Fas and Fas ligand (FasL) known to activate cleaved caspase-3, caspase-8, and polymeric adenosine diphosphate ribose (PARP) while decreasing the expression of death receptor 4 (DR4)
Cancer cells are destroyed whereas primary esophageal cells are protected when primary esophageal cells are cultured in a mixed population with type I cancer cells and treated with TRAIL in the presence of a caspase-9 inhibitor
To exert their intrinsic proapoptotic activities, all BH3-only molecules require multidomain BH3 proteins (Bax and Bak)
Phenoxodiol induces melanoma cell apoptosis by inducing p53-dependent BH3 proteins (PUMA, Noxa, and Bad) and p53-independent Bim protein, resulting in Bax activation and downstream events
Fisetin, an HSF1 inhibitor, acts as a triple inhibitor, lowering expression levels of Bcl-2, Mcl-1, and Bcl-x L via downregulation of their chaperones, BAG3 and HSP70. As a result, fisetin might be beneficial in combating single agent-induced resistance