Differences of Key Proteins between Apoptosis and Necroptosis

Table 3

Key proteins involved in both apoptosis and necroptosis.

Protein	Relation of apoptosis and necroptosis	References
RIPK1, RIPK3	In response to TNF, RIPK1 Asp325 is needed for reducing aberrant cell death	[44]
	Inhibiting caspase-8-mediated apoptosis as well as RIPK3-MLKL-dependent necroptosis fully prevents RIPK1-mediated embryonic mortality	[41]
Caspase-8	Caspase-8 is a molecular switch that controls apoptosis and necroptosis, as well as protecting tissues from injury	[42]
	Caspase-8 cleaves itself, other proteins, or both in order to prevent necroptosis	[44]